Parth Patel, MD, MBA1, Adam Vinall, MD1, Umesh Boregowda, MD1, Andrew Han, MD2, Sarah Marucci, MD1, Randy Wright, MD1, Juan Echavarria, MD1, Charles B. Miller, MD1, Prabhleen Chahal, MD, FACG1 1University of Texas Health San Antonio, San Antonio, TX; 2South Texas Veterans Health, San Antonio, TX
Introduction: Diabetes mellitus is an established risk factor for inadequate bowel preparation (IBP) before colonoscopy. However, the relationship between the degree of hyperglycemia and IBP has yielded inconsistent findings in previous studies. This study aims to investigate the association between glycemic control and inadequate bowel preparation.
Methods: A retrospective review was conducted on patients who underwent screening colonoscopy over 21 months at a tertiary academic center. Data collected included age, sex, type 2 diabetes status, A1c levels, bowel preparation adequacy, and medication use. Patients with diabetes and an A1c within six months were included. Cases (A1c ≥8) were compared to controls (A1c < 8) in a case-control design.
Results: The final analysis included 390 patients (mean age 60.2 years, 44.1% male). The mean A1c was 7.2 and the overall IBP rate was 17.6%. Patients with poor glycemic control had a 27.1% IBP rate, compared to 14.6% in those with good control (OR 2.2, CI 1.2-3.8, p=0.005). The mean A1c was 0.5 ± 0.3 points higher in patients with IBP (7.661 vs. 7.107, p=0.005). Multivariate logistic regression identified A1c as the only significant predictor of inadequate bowel preparation (OR 1.244, CI 1.045-1.482, p=0.014).
Discussion: This study aimed to identify the impact of glycemic control on inadequate bowel preparation (IBP). Poor glycemic control, measured by A1c ≥8.0% , significantly increases the risk of IBP. Insulin and GLP1RA use may also contribute; however, further dedicated studies will need to be performed.
Figure: Patient Characteristics for Case and Control Groups
Figure: Risk Factors for Bowel Preparation in Diabetics- UNIVARIATE ANALYSIS
Disclosures:
Parth Patel indicated no relevant financial relationships.
Adam Vinall indicated no relevant financial relationships.
Umesh Boregowda indicated no relevant financial relationships.
Andrew Han indicated no relevant financial relationships.
Sarah Marucci indicated no relevant financial relationships.
Randy Wright indicated no relevant financial relationships.
Juan Echavarria indicated no relevant financial relationships.
Charles Miller indicated no relevant financial relationships.
Prabhleen Chahal indicated no relevant financial relationships.
Parth Patel, MD, MBA1, Adam Vinall, MD1, Umesh Boregowda, MD1, Andrew Han, MD2, Sarah Marucci, MD1, Randy Wright, MD1, Juan Echavarria, MD1, Charles B. Miller, MD1, Prabhleen Chahal, MD, FACG1. P0864 - Effect of Glycemic Control on Bowel Preparation, ACG 2025 Annual Scientific Meeting Abstracts. Phoenix, AZ: American College of Gastroenterology.
