P4561 - Rapid, Sustained Quality of Life Gains and Gastrointestinal Symptom Relief After Colonoscopy: A Prospective Cohort Study

Mohamad Kedan, MBBCh¹, Mohamed Saad Rakab, ², Basel Hatem Elsalakawi, MBBCh³, Ali Mohammed Abdel-fatah, MBChB⁴, Mohammed Abumohsen, MBBCh⁵, Mohamed Elhusseini Elsaeidi, MBBCh⁶, Yusof M. Omar, MBBCh⁷, Hamza Aljubaeh, MBBCh⁶, Ahmed Abdelrafee, MBBCh⁸, Omar Hamdy, MBBCh⁸, Hamid U.. Rahman, MD⁹, Ahmed Abuhasna, DO⁹, Islam Rajab, MD¹⁰, Abdallah Hussein, MD¹¹, Abdalhakim Shubietah, MD⁹
1Mansoura University, Mansoura, Al Bahr al Ahmar, Egypt; 2Faculty of Medicine, Mansoura University, Mansoura, Egypt, Mansoura, Ad Daqahliyah, Egypt; 3Mansoura University, Mansoura, Al Minya, Egypt; 4Mansoura University, Mansoura, Al Minufiyah, Egypt; 5Mansoura University, Mansoura, Dumyat, Egypt; 6Mansoura University, Mansoura, Al Qahirah, Egypt; 7Mansoura University, Mansoura, Al Qalyubiyah, Egypt; 8Mansoura University, Mansoura, Al Iskandariyah, Egypt; 9Advocate Illinois Masonic Medical Center, Chicago, IL; 10St. Joseph's University Medical Center, Paterson, NJ; 11Virtua Our Lady of Lourdes Hospital, Camden, NJ

Introduction:

Whether colonoscopy temporarily worsens or relieves gastrointestinal symptoms remains unclear; we therefore tracked short-term changes in quality of life (QoL) and symptom severity in adults after the procedure.

Methods:

A single-center prospective cohort was conducted in Egypt, where 42 adult out-patients scheduled for diagnostic colonoscopy completed validated QoL and SSS questionnaires at baseline (pre-procedure), 10 days, and 30 days after colonoscopy; individuals in whom colorectal cancer was diagnosed were excluded. Because four of six score distributions were non-normal (Shapiro–Wilk p < 0.05), within-subject change was analyzed with the Friedman test followed by Holm-adjusted Wilcoxon signed-rank comparisons.

Results:

Quality of life improved overall (χ²₂ = 7.70, p = 0.021; Kendall W = 0.09, small effect). Median QoL rose from 62 (IQR 55–68) at baseline to 69 (63–75) at day 10 (p = 0.0176) and 75 (69–82) at day 30 (p = 0.0014); the 10-to-30-day increment was also significant (p = 0.0176). Symptom burden fell in mirror fashion (χ²₂ = 17.39, p < 0.001; W = 0.21, moderate effect). Median SSS declined from 277 (240–315) to 238 (200–275) at day 10 (p = 0.0233) and to 190 (150–225) at day 30 (p = 0.00044); the additional drop between day 10 and day 30 was significant (p = 0.00044). All six pairwise contrasts remained significant after Holm adjustment.

Discussion:

Among adults undergoing colonoscopy, health-related QoL rises, and symptom burden falls within ten days of the procedure and continues to improve through day 30. These findings suggest colonoscopy confers a rapid clinical benefit whose biological mechanisms and longer-term durability warrant further investigation.

Disclosures:


Mohamad Kedan, MBBCh¹, Mohamed Saad Rakab, ², Basel Hatem Elsalakawi, MBBCh³, Ali Mohammed Abdel-fatah, MBChB⁴, Mohammed Abumohsen, MBBCh⁵, Mohamed Elhusseini Elsaeidi, MBBCh⁶, Yusof M. Omar, MBBCh⁷, Hamza Aljubaeh, MBBCh⁶, Ahmed Abdelrafee, MBBCh⁸, Omar Hamdy, MBBCh⁸, Hamid U.. Rahman, MD⁹, Ahmed Abuhasna, DO⁹, Islam Rajab, MD¹⁰, Abdallah Hussein, MD¹¹, Abdalhakim Shubietah, MD⁹. P4561 - Rapid, Sustained Quality of Life Gains and Gastrointestinal Symptom Relief After Colonoscopy: A Prospective Cohort Study, ACG 2025 Annual Scientific Meeting Abstracts. Phoenix, AZ: American College of Gastroenterology.